Does growth hormone use the G protein linked mechanism to affect cells or does it use direct gene activation?

It's a cholesterol steroid hormone, right? So it uses direct gene activation? Or does it use G protein linked mechanism?

Does growth hormone use the G protein linked mechanism to affect cells or does it use direct gene activation?
The answer is neither. Growth hormone receptor is a cell surface receptor (like GPCRs), but it is not a 7 TM receptor and does not signal through G proteins. Instead, it activates a JAK-STAT kinase cascade that then translocates to the nucleus and activates gene expression.





So, while you are right that steroid hormone receptors often directly activate transcription, GH is a peptide, and goes through a kinase pathway.

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